Eficacia de la solución salina hipertónica frente al manitol en pacientes adultos con trauma craneoencefálico grave: revisión sistemática
DOI:
https://doi.org/10.36097/rgcs.v3i1.3213Palabras clave:
traumatismo craneoencefálico, hipertensión intracraneal, solución salina hipertónica, manitol, adultoResumen
El traumatismo craneoencefálico (TCE) grave es la principal causa de discapacidad y mortalidad a nivel mundial y para su manejo se han utilizado soluciones hiperosmolares sin una elección estandarizada. Se comparó la eficacia de la solución salina hipertónica (SHH) frente al manitol (MTL) en pacientes adultos con TCE grave o moderado potencialmente grave, evaluando la disminución de la presión intracraneal, nivel de conciencia y concentración de la osmolaridad sérica para identificar si existe superioridad de una sobre otra. Se incluyeron 9 artículos que cumplieron con los criterios de inclusión y exclusión establecidos con un total de 979 participantes con tamaños de muestra entre 20 a 502; el sesgo de los artículos fue analizado a través de escalas. La SHH presenta una superioridad en cuanto a su eficacia en comparación al MTL debido a su mecanismo de acción sostenido en el tiempo y menor recurrencia de episodios de hipertensión intracraneal.
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Derechos de autor 2026 Alexander Expósito, Amelie N. Silva, Nicolle M. Capelo, Carlos F. Zamora, Doris G. Cuji
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