Comparison between carbetocin and oxytocin in the prevention of postpartum hemorrhage in cesarean sections: a systematic review
DOI:
https://doi.org/10.36097/rgcs.v3i1.3198Keywords:
postpartum hemorrhage, cesarean section, oxytocin, carbetocin, mortalityAbstract
Postpartum hemorrhage is a leading cause of maternal mortality, particularly in women undergoing cesarean sections. This study aimed to compare the efficacy and safety of carbetocin versus oxytocin for the prevention of postpartum hemorrhage in women who have had a cesarean section, through a critical review and synthesis of the available evidence. A systematic review was conducted using the PRISMA guidelines. Studies comparing oxytocin and carbetocin in women with postpartum hemorrhage following cesarean section were searched in databases such as PubMed, Cochrane Library, Scopus, and Embase. The methodological quality of the studies was assessed using JADAD and Rob2 to determine the risk of bias. Seven studies published between 2015 and 2025, with a total of 848 participants, were included. The outcome parameters evaluated were blood loss (p= 0.12), use of additional uterotonics (p< 0.001), intensity of uterine tone (p= 1), and hemoglobin (p= 0.351). This systematic review concludes that there are no significant differences between the two drugs for postpartum hemorrhage (PPH) after cesarean section.
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