Glycated hemoglobin correlates with inflammatory markers of cardiovascular risk in patients with type 2 diabetes mellitus
DOI:
https://doi.org/10.36097/rgcs.v3i1.3197Keywords:
cardiovascular risk, type 2 diabetes mellitus, HbA1c, inflammationAbstract
Hyperglycemia promotes inflammation and increases cardiovascular risk. This study aimed to analyze the relationship between glycemic control and inflammatory and cardiovascular risk markers in patients with type 2 diabetes (T2DM). A cross-sectional, correlational study was conducted involving 300 adults (240 diabetics classified according to their HbA1c levels and 60 controls). Glucose, HbA1c, lipid profile, fibrinogen, high-sensitivity C-reactive protein (hs-CRP), atherogenix index of plasma (AIP), and erythrocyte sedimentation rate (ESR) were measured. Patients with T2DM had higher levels of fibrinogen, hs-CRP, AIP, and ESR compared to controls and among groups with poorer glycemic control (p<0.001). A significant positive correlation was observed between HbA1c and all biomarkers evaluated (p<0.0001). These findings support the use of HbA1c not only as an indicator of glycemic control but also as an indirect marker of cardiovascular risk in T2DM.
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The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
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